Glucagon-like action of N6, 2′-O-dibutyryl cyclic 3′,5′-AMP on perfused rat liver
1967; Elsevier BV; Volume: 29; Issue: 6 Linguagem: Inglês
10.1016/0006-291x(67)90303-8
ISSN1090-2104
AutoresLawrence A. Menahan, O. Wieland,
Tópico(s)Diet and metabolism studies
ResumoIn addition to its well-known glycogenolytic effect, glucagon has been shown to increase ketogenesis, gluconeogenesis and ureogenesis in the perfused livers of fasted rats (1,2). Cyclic 3′,5′-AMP (cAMP) has been postulated as the mediator or “second messenger” of glucagon action on liver, with particular reference to its glycogenolytic effect (3). The present report indicates that, following N6, 2′-O-dibutyryl cyclic 3′,5′-AMP (DBcAMP) addition to the perfusion medium, an increase in endogenous urea, glucose and ketone body production occurs in the isolated, perfused liver from fasted rats. This would add substantial support to the hypothesis that cyclic 3′,5′-AMP is the mediator of the effects of glucagon on gluconeogenesis, ketogenesis and ureogenesis.
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