Serotonergic terminals express a growth associated protein (GAP-43) in the adult rat spinal cord
1994; Elsevier BV; Volume: 167; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(94)91029-4
ISSN1872-7972
AutoresChing C. Lau, Sharon Averill, Graham P. Wilkin, Glen Wotherspoon, John V. Priestley,
Tópico(s)Neurogenesis and neuroplasticity mechanisms
ResumoDual colour immunofluorescence has been used to compare the distribution of serotonin (5-hydroxytryptamine, 5-HT) and GAP-43 in the adult rat. GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GAP-43 double labelled fibres and varicosities were present and were most evident around motoneurones, in lamina X, and in the intermediolateral cell column. Single labelled GAP-43 fibres and varicosities were also observed and were the dominant population in the dorsal horn and in certain fibre tracts. We conclude that the 5-HT system is one of a small number of spinal cord systems that express high levels of GAP-43 in the adult.
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