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Screening of CHCHD10 in a French cohort confirms the involvement of this gene in frontotemporal dementia with amyotrophic lateral sclerosis patients

2014; Elsevier BV; Volume: 35; Issue: 12 Linguagem: Inglês

10.1016/j.neurobiolaging.2014.07.022

1558-1497

Annabelle Chaussenot, Isabelle Le Ber, Samira Ait-El-Mkadem, Agnès Camuzat, Anne de Septenville, Sylvie Bannwarth, Emmanuelle C. Genin, Valérie Serre, Gaëlle Augé, Alexis Brice, Jean Pouget, Véronique Paquis‐Flucklinger,

Mitochondrial Function and Pathology

Mutations in the CHCHD10 gene have been recently identified in a large family with a complex phenotype variably associating frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS), cerebellar ataxia, myopathy, and hearing impairment. CHCHD10 encodes a protein located in the mitochondrial intermembrane space and is likely involved in mitochondrial genome stability and maintenance of cristae junctions. However, the exact contribution of CHCHD10 in FTD and ALS diseases spectrum remains unknown. In this study, we evaluated the frequency of CHCHD10 mutations in 115 patients with FTD and FTD-ALS phenotypes. We identified 2 heterozygous variants in 3 unrelated probands presenting FTD and ALS, characterized by early and predominant bulbar symptoms. This study demonstrates the implication of CHCHD10 in FTD and ALS spectrum. Although the frequency of mutations is low in this series (2.6%), our work suggests that CHCHD10 mutations should be searched particularly when bulbar symptoms are present at onset.