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Controlled Comparison of Tianeptine, Alprazolam and Mianserin in the Treatment of Adjustment Disorders with Anxiety and Depression

1996; Wiley; Volume: 11; Issue: 4 Linguagem: Inglês

10.1002/(sici)1099-1077(199607)11

1099-1077

Marc Ansseau, Michel Bataille, G Briole, ANDR� DE NAYER, PIERRE ANDR� FAUCH�RE, F Ferrero, C. Mertens, Renzo Realini, Philippe Rombaut, ANDR� VEREECKEN, BENO�T TROISFONTAINES, Myriam Van Moffaert,

Bipolar Disorder and Treatment

Human Psychopharmacology: Clinical and ExperimentalVolume 11, Issue 4 p. 293-298 Research Article Controlled Comparison of Tianeptine, Alprazolam and Mianserin in the Treatment of Adjustment Disorders with Anxiety and Depression MARC ANSSEAU, MARC ANSSEAU Department of Psychiatry and Medical Psychology, C.H.U. du Sart Tilman, B-4000 Liège, BelgiumSearch for more papers by this authorMICHEL BATAILLE, MICHEL BATAILLE Clinique Notre-Dame, B-4681 Hermalle s/Argenteau, BelgiumSearch for more papers by this authorGUY BRIOLE, GUY BRIOLE Centre d'Instruction des Armées du Val de Grâce, F-75230 Paris, FranceSearch for more papers by this authorANDRÉ DE NAYER, ANDRÉ DE NAYER Clinique Sainte-Thérèse, B-6061 Montignies-sur-Sambre, BelgiumSearch for more papers by this authorPIERRE ANDRÉ FAUCHÈRE, PIERRE ANDRÉ FAUCHÈRE CH-1950 Sion, SwitzerlandSearch for more papers by this authorFRANÇOIS FERRERO, FRANÇOIS FERRERO Policlinique Psychiatrique Universitaire B, CH-1005 Lausanne, SwitzerlandSearch for more papers by this authorCLAUDINE MERTENS, CLAUDINE MERTENS Psychiatrische Centra Sleidinge, B-9940 Evergem–Sleidinge, BelgiumSearch for more papers by this authorRENZO REALINI, RENZO REALINI CH-6900 Lugano, SwitzerlandSearch for more papers by this authorPHILIPPE ROMBAUT, PHILIPPE ROMBAUT Psychiatrisch Ziekenhuis Sint Jan, B-9900 Eeklo, BelgiumSearch for more papers by this authorANDRÉ VEREECKEN, ANDRÉ VEREECKEN Psychiatrisch Ziekenhuis Sint Jan, B-9900 Eeklo, BelgiumSearch for more papers by this authorBENOÎT TROISFONTAINES, BENOÎT TROISFONTAINES Clinique Saint-Vincent, B-4000 Rocourt, BelgiumSearch for more papers by this authorMYRIAM VAN MOFFAERT, MYRIAM VAN MOFFAERT Psychiatrische Kliniek, Akademisch Ziekenhuis, B-9000 Gent, BelgiumSearch for more papers by this author MARC ANSSEAU, MARC ANSSEAU Department of Psychiatry and Medical Psychology, C.H.U. du Sart Tilman, B-4000 Liège, BelgiumSearch for more papers by this authorMICHEL BATAILLE, MICHEL BATAILLE Clinique Notre-Dame, B-4681 Hermalle s/Argenteau, BelgiumSearch for more papers by this authorGUY BRIOLE, GUY BRIOLE Centre d'Instruction des Armées du Val de Grâce, F-75230 Paris, FranceSearch for more papers by this authorANDRÉ DE NAYER, ANDRÉ DE NAYER Clinique Sainte-Thérèse, B-6061 Montignies-sur-Sambre, BelgiumSearch for more papers by this authorPIERRE ANDRÉ FAUCHÈRE, PIERRE ANDRÉ FAUCHÈRE CH-1950 Sion, SwitzerlandSearch for more papers by this authorFRANÇOIS FERRERO, FRANÇOIS FERRERO Policlinique Psychiatrique Universitaire B, CH-1005 Lausanne, SwitzerlandSearch for more papers by this authorCLAUDINE MERTENS, CLAUDINE MERTENS Psychiatrische Centra Sleidinge, B-9940 Evergem–Sleidinge, BelgiumSearch for more papers by this authorRENZO REALINI, RENZO REALINI CH-6900 Lugano, SwitzerlandSearch for more papers by this authorPHILIPPE ROMBAUT, PHILIPPE ROMBAUT Psychiatrisch Ziekenhuis Sint Jan, B-9900 Eeklo, BelgiumSearch for more papers by this authorANDRÉ VEREECKEN, ANDRÉ VEREECKEN Psychiatrisch Ziekenhuis Sint Jan, B-9900 Eeklo, BelgiumSearch for more papers by this authorBENOÎT TROISFONTAINES, BENOÎT TROISFONTAINES Clinique Saint-Vincent, B-4000 Rocourt, BelgiumSearch for more papers by this authorMYRIAM VAN MOFFAERT, MYRIAM VAN MOFFAERT Psychiatrische Kliniek, Akademisch Ziekenhuis, B-9000 Gent, BelgiumSearch for more papers by this author First published: July 1996 https://doi.org/10.1002/(SICI)1099-1077(199607)11:4 3.0.CO;2-ZCitations: 26AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract A multicentre study compared tianeptine (37·5 mg/day), an original psychotropic compound characterized by both antidepressant and anxiolytic potentials, with a reference antidepressant, mianserin (60 mg/day) and a reference anxiolytic, alprazolam (1·5 mg/day), in the treatment of 152 patients fulfilling DSM-III-R criteria for adjustment disorder with mixed emotional features (anxiety and depression). The study used a double-blind parallel design over a 6-week period. Clinical assessments included the Clinical Global Impressions (CGI), the Montgomery and Asberg depression rating scale (MADRS), the Hamilton anxiety rating scale, a visual analogue scale, and the somatic scale of the system developed by the Association for the Methodology and Documentation in Psychiatry (AMDP). Results showed very similar improvement in the three treatment groups on all rating instruments. Moreover, the number of patients exhibiting adverse events did not differ among the three groups. Therefore, these results show similar antidepressant and anxiolytic activity for tianeptine, mianserin and alprazolam in patients suffering from adjustment disorder with mixed emotional features. These promising findings should however be confirmed in a placebo-controlled trial. Citing Literature Volume11, Issue4July 1996Pages 293-298 RelatedInformation