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Porphyrins in the Bone Marrow and Circulating Erythrocytes in Experimental Anemias.

1950; SAGE Publishing; Volume: 75; Issue: 3 Linguagem: Inglês

10.3181/00379727-75-18312

1535-3702

R. Schmid, Samuel Schwartz, C. J. Watson,

Erythrocyte Function and Pathophysiology

1. The copro-and protoporphyrins of bone marrow and circulating erythrocytes in the rabbit have been found to exhibit dynamic changes under a variety of stimuli to erythropoiesis, including lead poisoning, phenylhydrazine, hemorrhage, and reduced oxygen tension. These consist of (1) a striking increase of coproporphyrin in the developing erythrocytes of the bone marrow, with a marked relative reduction of its concentration in circulating red blood cells, (2) an inconstant but generally increased level of protoporphyrin in the circulating as compared with the marrow erythrocytes. 2. These observations point to a close relationship between coproporphyrin and hemoglobin synthesis, and appear to be consistent with concepts which consider coproporphyrin either as a direct precursor of hemoglobin protoporphyrin or as a by-product of the synthesis. The former concept, however, seems to permit a more reasonable correlation of the porphyrin findings in bone marrow and blood with those in urine and feces.