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Afferent vagal stimulation: Neurographic correlates of induced eeg synchronization and desynchronization

1967; Elsevier BV; Volume: 5; Issue: 2 Linguagem: Inglês

10.1016/0006-8993(67)90089-3

1872-6240

Michael H. Chase, Yoshio Nakamura, Carmine Clemente, M. B. Sterman,

Neural dynamics and brain function

Summaryo1.Cortical synchronization and desynchronization were induced by afferent cervical vagal stimulation in the cat.2.By simultaneously recording the vagal neurogram and the induced EEG responses, it was determined that rapidly conducted vagal potentials were associated with EEG synchronization, while potentials conducted at approximately 15 m/sec were correlated with EEG desynchronization.3.The specific factor which determined the nature of the EEG response was whether synchronogenic or desynchronogenic vagal afferent fibers were stimulated and not the frequency of stimulation.4.Following supranodose transection of the vagus nerve, the sensory elements remaining in the vagus could be stimulated to induce a vagal neurogram which contained the potential complexes seen in the intact nerve and which had been correlated with the induced EEG responses. A histologic analysis of intact and transected vagi confirmed the neurographic findings.5.The patterns of the induced synchronization which occur as a result of afferent vagal stimulation are similar to those which occur spontaneously or during quiet sleep in the unrestrained cat. It was concluded that the vagal afferent system is comprised of fiber groups which are able to initiate and maintain either synchronization or desynchronization of the EEG and that these fiber groups are both functionally and structurally discrete. Cortical synchronization and desynchronization were induced by afferent cervical vagal stimulation in the cat. By simultaneously recording the vagal neurogram and the induced EEG responses, it was determined that rapidly conducted vagal potentials were associated with EEG synchronization, while potentials conducted at approximately 15 m/sec were correlated with EEG desynchronization. The specific factor which determined the nature of the EEG response was whether synchronogenic or desynchronogenic vagal afferent fibers were stimulated and not the frequency of stimulation. Following supranodose transection of the vagus nerve, the sensory elements remaining in the vagus could be stimulated to induce a vagal neurogram which contained the potential complexes seen in the intact nerve and which had been correlated with the induced EEG responses. A histologic analysis of intact and transected vagi confirmed the neurographic findings. The patterns of the induced synchronization which occur as a result of afferent vagal stimulation are similar to those which occur spontaneously or during quiet sleep in the unrestrained cat. It was concluded that the vagal afferent system is comprised of fiber groups which are able to initiate and maintain either synchronization or desynchronization of the EEG and that these fiber groups are both functionally and structurally discrete.