Declining breast cancer incidence and decreased HRT use
2008; Elsevier BV; Volume: 372; Issue: 9639 Linguagem: Inglês
10.1016/s0140-6736(08)61255-6
ISSN1474-547X
Autores Tópico(s)Menopause: Health Impacts and Treatments
ResumoBreast cancer is the most common cancer in women worldwide, comprising 23% of all cancers, with more than 1 million new cases per year. 1 Parkin DM Bray F Ferlay J Pisani P Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55: 74-108 Crossref PubMed Scopus (17222) Google Scholar The main risk factors are related to the female sex hormones with oestrogenic and progestagenic activity either produced within the body or given as hormonal contraceptives or hormone-replacement therapy (HRT). Changes in reproductive factors, use of postmenopausal HRT, mammographic screening, and lifestyle factors associated with affluence have been contributing to the increase in breast cancer witnessed during the past few decades in women aged 50 years or older from developed countries.
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