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Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats

2004; Elsevier BV; Volume: 314; Issue: 3 Linguagem: Inglês

10.1016/j.bbrc.2003.12.180

1090-2104

Taku Masuyama, Kajuro Komeda, Akemi Hara, Mitsuhiko Noda, Masami Shinohara, Toshihiro Oikawa, Yasunori Kanazawa, Kazuyuki TANIGUCHI,

Diabetes and associated disorders

To characterize the underlying mechanisms of diabetes development in males of the Spontaneously Diabetic Torii (SDT) rat, a novel spontaneous model for diabetes, we chronologically examined them, focusing on their diabetic features and the pathological changes in the pancreatic islets. Male SDT rats exhibited glucose intolerance with impaired insulin secretion after 14 weeks and developed diabetes with remarkable hyperglycemia and marked hypoinsulinemia after 20 weeks. At prediabetic stage (10–20 weeks), they were normoglycemic, but had significantly lower insulin levels of plasma and pancreas than the normal rats. Their β-cell volume was already smaller significantly at 10 weeks than that of normal rats. The primary changes of the pancreatic islets were microvascular events such as congestion and hemorrhage at 8–10 weeks. Thereafter, the SDT rat islets were affected with inflammation and progressive fibrosis (at 10–20 weeks), and eventually atrophied with a loss of β-cells (at 38 weeks). These results indicate that the male SDT rats develop spontaneous diabetes with an absolute decrease in the insulin secretory capacity of the islets.