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Specific Reading Disability: Identification of an Inherited Form Through Linkage Analysis

1983; American Association for the Advancement of Science; Volume: 219; Issue: 4590 Linguagem: Inglês

10.1126/science.6828864

1095-9203

Shelley D. Smith, William J. Kimberling, Bruce F. Pennington, Herbert A. Lubs,

Reading and Literacy Development

Linkage analysis in families with apparent autosomal dominant reading disability produced a lod score of 3.241. Since the traditionally accepted significance level for linkage is a lod score of 3.0, these results strongly suggest that a gene playing a major etiologic role in one form of reading disability is on chromosome 15.