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The FcγRIIa polymorphism in patients with chronic kidney graft rejection

2004; Elsevier BV; Volume: 36; Issue: 5 Linguagem: Inglês

10.1016/j.transproceed.2004.05.076

1873-2623

Andrzej Pawlik, Marcin Florczak, Bak L, Ewa Dąbrowska‐Żamojcin, Jacek Różański, Leszek Domański, B Gawrońska-Szklarz,

Renal Transplantation Outcomes and Treatments

The FcγRIIa receptors, which provide a crucial link between cellular and humoral components of the immune response, display allelic polymorphism. Individuals are homozygous for either arginine 131 (RR131) or histidine 131 (HH131) or are heterozygous for these two alleles (RH131). The HH131 genotype binds human IgG2 with high RR131 with low, and RH131 with intermediate affinity. The aim of the study was to evaluate the FcγRIIa polymorphism in patients with chronic kidney graft rejection. The study included 121 renal transplant recipients: 53 patients with long-term stable graft function and 68 with chronic allograft rejection. The distribution of FcγRIIa genotypes in patients with chronic kidney graft rejection did not differ significantly from that in patients with stable graft function. The results suggest that the FcγRIIa polymorphism is not an important genetic risk factor for chronic rejection of kidney allografts.