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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Expression of endo-oligopeptidase A in the rat central nervous system: a non-radioactive in situ hybridization study

2001; Elsevier BV; Volume: 89; Issue: 1-2 Linguagem: Inglês

10.1016/s0169-328x(01)00066-3

ISSN

1872-6941

Autores

Mirian A.F. Hayashi, Raquel S. Pires, Nancy Amaral Rebouças, Luiz Roberto Britto, Antônio Carlos Martins de Camargo,

Tópico(s)

Signaling Pathways in Disease

Resumo

Endo-oligopeptidase A (EOPA, formerly EC 3.4.22.19), a thiol-activated oligopeptidase, is able to degrade both bradykinin and neurotensin, and also to convert enkephalin-containing peptides into enkephalins. The expression of this enzyme was studied in the rat brain by in situ hybridization using non-radiotopic probes. The distribution of EOPA transcripts included many regions of the rat central nervous system, with higher expression in some regions, such as the hippocampus, cerebellum, and basal nucleus of Meynert. The marked EOPA expression in these areas could be anticipated, since they are rich in neuropeptides that are known to be EOPA substrates in vitro. The data characterize a widespread occurrence of EOPA in the rat brain and reinforce the suggestion of a critical role for EOPA in peptide processing.

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