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β A4 amyloid protein and its precursor in Alzheimer's disease

1992; Elsevier BV; Volume: 56; Issue: 1 Linguagem: Inglês

10.1016/0163-7258(92)90039-3

1879-016X

Ashley I. Bush, Konrad Beyreuther, Colin L. Masters,

Prion Diseases and Protein Misfolding

The βA4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.