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Steroidal Sapogenins and Glycosides from the Rhizomes of Dioscorea bulbifera

2009; American Chemical Society; Volume: 72; Issue: 11 Linguagem: Inglês

10.1021/np900255h

1520-6025

Hai Liu, Gui‐Xin Chou, Tao Wu, Yinlong Guo, Shunchun Wang, Changhong Wang, Zhengtao Wang,

Marine Sponges and Natural Products

Four new steroidal sapogenins (1−4), named diosbulbisins A−D, two new spirostane glycosides, diosbulbisides A (5) and B (6), one new cholestane glycoside, diosbulbiside C (7), and the known compounds 8−10 were isolated from rhizomes of Dioscorea bulbifera. Their structures were elucidated by 1D and 2D NMR techniques, HRFTMS, and chemical methods. The unusual furospirostanol sapogenin skeletons, as found in compounds 3 and 4, are reported in the family Dioscoreaceae for the first time. Cytotoxicity of compounds 1−10 was evaluated using two human hepatocellular carcinoma cell lines (Bel-7402 and SMMC7721).