VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND TUMOR ANGIOGENESIS ARE REGULATED BY ANDROGENS IN HORMONE RESPONSIVE HUMAN PROSTATE CARCINOMA: : EVIDENCE FOR ANDROGEN DEPENDENT DESTABILIZATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR TRANSCRIPTS
2001; Lippincott Williams & Wilkins; Volume: 165; Issue: 2 Linguagem: Inglês
10.1097/00005392-200102000-00095
ISSN1527-3792
AutoresRobert Stewart, Dipak Panigrahy, Evelyn Flynn, Judah Folkman,
Tópico(s)Estrogen and related hormone effects
ResumoNo AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Feb 2001VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND TUMOR ANGIOGENESIS ARE REGULATED BY ANDROGENS IN HORMONE RESPONSIVE HUMAN PROSTATE CARCINOMA: : EVIDENCE FOR ANDROGEN DEPENDENT DESTABILIZATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR TRANSCRIPTS ROBERT J. STEWART, DIPAK PANIGRAHY, EVELYN FLYNN, and JUDAH FOLKMAN ROBERT J. STEWARTROBERT J. STEWART , DIPAK PANIGRAHYDIPAK PANIGRAHY , EVELYN FLYNNEVELYN FLYNN , and JUDAH FOLKMANJUDAH FOLKMAN View All Author Informationhttps://doi.org/10.1097/00005392-200102000-00095AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The hormonally regulated growth of some human carcinomas represents an important therapeutic target. We report that androgens modulate the angiogenic activity of hormone responsive human prostate cancer. Materials and Methods: To define further the critical mechanisms underlying hormone responsiveness we examined the angiogenic mediator, vascular endothelial growth factor messenger (m) RNA and protein in response to androgens in vitro as well as the angiogenic response of xenografts of human prostate cancer after androgen withdrawal in vivo. Results: In vitro androgen deprivation of LnCaP prostate cancer cells led to decreased vascular endothelial growth factor mRNA and protein expression as well as a 5-fold destabilization in vascular endothelial growth factor mRNA transcripts. In addition, androgen withdrawal inhibited the hypoxic induction of vascular endothelial growth factor mRNA. In mice bearing LnCaP tumors castration resulted in a rapid decrease in mRNA expression and markedly reduced tumor neovascularization. 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Google Scholar From the Department of Surgery, University of Toronto, Toronto, Ontario, Canada, and Departments of Surgery and Cell Biology, Harvard Medical School, Children's Hospital, Boston, Massachusetts© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byTaneja S (2018) Re: Aflibercept versus Placebo in Combination with Docetaxel and Prednisone for Treatment of Men with Metastatic Castration-Resistant Prostate Cancer (VENICE): A Phase 3, Double-Blind Randomised TrialJournal of Urology, VOL. 191, NO. 3, (656-657), Online publication date: 1-Mar-2014.SCHATZL G, MADERSBACHER S, HAITEL A, GSUR A, PREYER M, HAIDINGER G, GASSNER C, OCHSNER M and MARBERGER M (2018) Associations of Serum Testosterone with Microvessel Density, Androgen Receptor Density and Androgen Receptor Gene polymorphism In prostate cancerJournal of Urology, VOL. 169, NO. 4, (1312-1315), Online publication date: 1-Apr-2003. Volume 165Issue 2February 2001Page: 688-693 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsandrogensneovascularization, pathologicgrowth substancesprostateprostatic neoplasmsMetricsAuthor Information ROBERT J. STEWART More articles by this author DIPAK PANIGRAHY More articles by this author EVELYN FLYNN More articles by this author JUDAH FOLKMAN More articles by this author Expand All Advertisement PDF downloadLoading ...
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