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BIBTEX RIS

Varicella zoster virus DNA does not accumulate in infected human neurons

2014; Elsevier BV; Volume: 458-459; Linguagem: Inglês

10.1016/j.virol.2014.04.014

ISSN

1096-0341

Autores

Nicholas L. Baird, Jacqueline L. Bowlin, Xiaoli Yu, Stipan Jonjić, Jürgen Haas, Randall J. Cohrs, Don Gilden,

Tópico(s)

Mosquito-borne diseases and control

Resumo

Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA.

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