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BIBTEX RIS

Serrated adenoma and colorectal cancer

1999; Volume: 187; Issue: 5 Linguagem: Inglês

10.1002/(sici)1096-9896(199904)187

ISSN

1096-9896

Autores

Jeremy R. Jass,

Tópico(s)

Cholangiocarcinoma and Gallbladder Cancer Studies

Resumo

Hyperplastic polyps and serrated adenomas of the colorectum show mixed gastrointestinal differentiation, expressing both gastric (M1 or MUC5AC) and intestinal (MUC2) mucins. They also share the phenotype of mild DNA microsatellite instability (MSI-L). Recent findings of clonal genetic changes within hyperplastic polyps fit with a pathway of serrated neoplasia, perhaps culminating in the subset of colorectal cancer characterized by the mild mutator phenotype. Copyright © 1999 John Wiley & Sons, Ltd.

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