Produção Nacional
Revisado por pares
Changes in the volume and histology of endometriosis foci in rats treated with copaiba oil (Copaiferalangsdorffii)
2011; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 26; Issue: suppl 2 Linguagem: Inglês
10.1590/s0102-86502011000800005
ISSN1678-2674
AutoresJoão Nogueira Neto, Márcio Jorge de Souza Lindoso, Laura Fernandes Coelho, Rafael Antonio Freire Carvalho, Taciana Gabrielle Pinheiro de Moura Rodrigues, Ana Gisélia Portela de Araújo, Manuel João Batista Castelo Girão, Eduardo Schor,
Tópico(s)Plant Toxicity and Pharmacological Properties
ResumoPURPOSE: The aim of this study was to analyze the changes that occur in rats with experimental endometriosis after treatment with copaiba oil. METHODS: Experimental endometriosis was induced in rats. The experimental group received copaiba oil (Copaiferalangsdorffii) orally (0.63 mg/day), and the control group received a 0.9% sodium chloride solution orally (1 ml/100 g of body weight/day). Both groups were treated with gavage for 14 days. After this period, the animals were euthanized, and the implant volume was calculated. The autologous transplants were removed, dyed with hematoxylin-eosin, and analyzed by light microscopy. RESULTS: The average final volumes were significantly different between the groups (p=0.007). There was a significant increase (p=0.012) between the initial and final volumes in the control group, whereas treatment with Copaiferalangsdorffii caused a marked reduction in endometrial growth over time (p=0.016). Histologically, 6/11 (55.00%) rats in the experimental group had a well-preserved epithelial layer, and 3 (45.00%) had mildly preserved epithelium. The control group had seven cases (58.30%) of well-preserved epithelial cells and five cases (41.70%) of mildly preserved epithelial cells (p>0.05). CONCLUSION: Copaiba oil (Copaiferalangsdorffii) appears to be a promising alternative treatment for endometriosis.
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