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Patients with intractable epilepsy have low melatonin, which increases following seizures

2000; Lippincott Williams & Wilkins; Volume: 55; Issue: 11 Linguagem: Inglês

10.1212/wnl.55.11.1746

1526-632X

Carl W. Bazil, Douglas W. Short, David A. Crispin, Wei Zheng,

Sleep and Wakefulness Research

Article abstract Melatonin, which is used to treat sleep disorders, has anticonvulsant properties. The authors measured salivary melatonin and cortisol, at baseline and following seizures, in patients with intractable temporal lobe epilepsy and controls. Melatonin was reduced in patients with epilepsy at baseline compared with controls, and increased threefold following seizures. Cortisol also increased following seizures. Patients with intractable epilepsy have low baseline melatonin levels that increase dramatically following seizures.