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Uricosuric Agents in the Treatment of Gout

1960; BMJ; Volume: 19; Issue: 4 Linguagem: Inglês

10.1136/ard.19.4.351

1468-2060

G. D. Kersley, A R Gibbs,

Urticaria and Related Conditions

During the past 2 years an attempt has been made to assess the relative value and toxicity of various uricosuric agents.Previous Investigations Kersley, Cook, and Tovey (1958) reported the therapeutic value of G.28 315 (sulphinpyrazone), a phenylbutazone derivative now known as Anturan (Geigy), in a group of fifteen patients with gout in a clinical trial lasting 3 to 8 months.Benemid and Longacid (Urelim), a benemid-like drug (Ward, Blenkinsop and Co.), were also given in selected cases.The results, as shown by estimations of the urinary uric acid excretion and the serum uric acid, are summarized in the Table (Rows 1-4).Anturan was the most efficacious drug, although the other two also had a definite uricosuric effect.Inter- mittent administration 3 days per week was not effective.It was found that the use of 3 5 g.aspirin as an analgesic completely inhibited the effect of Anturan in the doses given (Table ,Row 5).