Identification of Profilin as a Novel Pollen Allergen; IgE Autoreactivity in Sensitized Individuals
1991; American Association for the Advancement of Science; Volume: 253; Issue: 5019 Linguagem: Inglês
10.1126/science.1857985
ISSN1095-9203
AutoresRudolf Valenta, Michael Duchêne, K. Pettenburger, Christian Sillaber, Peter Valent, Peter Bettelheim, Michael Breitenbach, Helmut Rumpold, Dietrich Kraft, Otto Scheiner,
Tópico(s)Contact Dermatitis and Allergies
ResumoA complementary DNA encoding a pollen allergen from white birch ( Betula verrucosa ) that was isolated from a pollen complementary DNA library with serum immunoglobulin E from a birch pollen-allergic individual revealed significant sequence homology to profilins. The recombinant protein showed high affinity to poly-L-proline. Immunoglobulin E antibodies from allergic individuals bound to natural and recombinant birch profilin and also to human profilin. In addition, birch and human profilin induced histamine release from blood basophils of profilin-allergic individuals, but not of individuals sensitized to other plant allergens. The structural similarity of conserved proteins might therefore be responsible for maintaining immunoglobulin E antibody titers in type I allergy.
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