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BIBTEX RIS

Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

2008; American Association for the Advancement of Science; Volume: 319; Issue: 5871 Linguagem: Inglês

10.1126/science.1150843

ISSN

1095-9203

Autores

Leighton J. Core, John T. Lis,

Tópico(s)

RNA modifications and cancer

Resumo

Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.

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