T‐lymphocytes and the pathogenesis of type 1 (insulin‐dependent) diabetes mellitus
1992; Wiley; Volume: 22; Issue: 11 Linguagem: Inglês
10.1111/j.1365-2362.1992.tb01433.x
ISSN1365-2362
AutoresBart O. Roep, René R. P. de Vries,
Tópico(s)Diabetes Management and Research
ResumoEuropean Journal of Clinical InvestigationVolume 22, Issue 11 p. 697-711 T-lymphocytes and the pathogenesis of type 1 (insulin-dependent) diabetes mellitus B. O. ROEP, Corresponding Author B. O. ROEP Department of Immunohaematology and Blood Bank, University Hospital Leiden, The NetherlandsDepartment of Immunohaematology and Blood Bank, University Hospital Leiden, The Netherlands.Search for more papers by this authorR. R. P. DE VRIES, R. R. P. DE VRIES Department of Immunohaematology and Blood Bank, University Hospital Leiden, The NetherlandsSearch for more papers by this author B. O. ROEP, Corresponding Author B. O. ROEP Department of Immunohaematology and Blood Bank, University Hospital Leiden, The NetherlandsDepartment of Immunohaematology and Blood Bank, University Hospital Leiden, The Netherlands.Search for more papers by this authorR. R. P. DE VRIES, R. R. P. DE VRIES Department of Immunohaematology and Blood Bank, University Hospital Leiden, The NetherlandsSearch for more papers by this author First published: November 1992 https://doi.org/10.1111/j.1365-2362.1992.tb01433.xCitations: 20AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Unanue ER, Allen PM. The basis for the immunoregulatory role of macrophages and other accessory cells. Science 1987; 236: 551– 7. 2 Sette A., Buus S., Colon S., Smith JA, Miles C., Grey HM. Structural characteristics of an antigen required for its interaction with la and recognition by T cells. Nature 1987; 328: 395– 9. 3 Schwartz RH. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Ann Rev Immunol 1985; 3: 237. 4 Kappler JW, Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987; 49: 273– 80. 5 Svejgaard A., Platz P., Ryder LP. HLA and disease 1982—a survey. Immunol Rev 1983; 70: 193– 218. 6 Rocp BO, Bontrop RE, Pena AS, van Eggermond MCLA, van Rood JJ, Giphart MJ. An HLA alpha allele identified at DNA and protein level is strongly associated with celiac disease. Hum Immunol 1988; 23: 271– 9. 7 Sollid LM, Markussen G., Ek J., Gjerde H., Vartdal F., Thorsby E. Evidence for a primary association of celiac disease to a particular HLA-DQalpha/β heterodimer. J Exp Med 1989; 169: 345– 50. 8 Bugawan TL, Angelini G., Larrick J., Aurcchio S., Ferrara GB, Erlich HA. A combination of a particular HLA-DPβ allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease. Nature 1989; 339: 470– 3. 9 Nepom BS, Schwatrz D., Palmer JP, Nepom GT. Transcomple-mentation of HLA genes in IDDM. HLA-DQalpha- and β-chains produce hybrid molecules in DR3/4 heterozygotes. Diabetes 1987; 36: 114– 17. 10 Schreuder GMTh, Tilanus MGJ, Bontrop RE et al. HLA-DQ polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences and restriction fragment length polymorphism. J Exp Med 1986; 164: 938– 43. 11 Todd JA, Acha-Orbea H., Bell JI et al. A molecular basis for MHC class II-associated autoimmunity. Science 1988; 240: 1003– 9. 12 Todd JA, Bell JI, McDevitt HO. HLA-DQ beta gene contributes to susceptibility to insulin-dependent diabetes mellitus. Nature 1987; 329: 599. 13 Klitz W. Inheritance of insulin-dependent diabetes mellitus. Nature 1988; 333: 402– 3. 14 Erlich HA. HLA and insulin dependent diabetes mellitus. Nature 1989; 337: 415. 15 Kahlil I., D'Auriol L., Gobet M., Morin L., Lepage V., Deschamps I., Park MS, Degos L., Gaibert F., Hors J. A combination of HLA-DQβ Asp57-negative and HLA-DQalpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus. J Cliri Invest 1990; 85: 1315– 19. 16 Altmann DM, Sansom D., Marsh SGE. What is the basis for HLA-DQ associations with autoimmune disease Immunol Today 1991; 12: 267– 70. 17 van Vleit E., Roep BO, Meulenbroek L., Bruining GJ, de Vries RRP. Human T cell clones with specificity for insulinoma cell antigens. Eur J Immunol 1989; 19: 213– 6. 18 Roep BO, Kalian A. A., Hazenbos WLW, Bruining GJ, Bailyes EM, Arden SD, Hutton JC, de Vries RRP. T-cell reactivity to 38kDa insulin-secretory granule protein in patients with recent onset type 1 diabetes. Lancet 1991; 337: 1439– 41. 19 Giphart MJ, Roep BO, Drabbels J., D'Amaro J., Bruining GJ, Abdulkadir J., Verduyn W. Relative contribution of HLA-DQA and -DQB alleles to predisposition to insulin-dependent diabetes mellitus. Hum Immunol 1992; 34: 142– 6. 20 Ziegler AG, Standl E., Albert E., Mehnert H. HLA-associated insulin-autoantibody formation in newly diagnosed type-1 diabetes patients. Diabetes 1991; 40: 1146– 9. 21 Fineberg SE, Biegel AA, Durr K.L, Hufferd S., Fineberg NS, Anderson JH. Presence of insulin autoantibodies as regular feature of nondiabetic repertoire of immunity. Diabetes 1991; 40: 1187– 93. 22 Deverson EV, Gow IR, Coadwell WJ, Monaco JJ, Butcher GW, Howard JC. MHC class II region encoding proteins related to multidrug resistance. Nature 1990; 348: 738– 41. 23 Spies T., de Mars R. Restored expression of major histocompa-tibility class I molecules by gene transfer of a putative peptide transporter. Nature 1991; 35I: 323– 4. 24 Garchon H-J, Bedossa P., Eloy L., Bach J-F. Identification and mapping to chromosome 1 of a susceptibility locus for periinsu-litis in non-obese diabetic mice. Nature 1991; 353: 260– 2. 25 Cornall RJ, Prins J-B, Todd JA, Pressey A., DeLarato NH, Wicker LS, Peterson LBN. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1. Nature 1991; 353: 262– 5. 26 Dawkins RL, Martin E., Saueracker G., Kay PH, Leaver A., Christiansen FT. Supratypes and ancestral haplotypes in IDDM: potential importance of central non-HLA MHC genes. J Autoimmunity 1990; 1: 63– 8. 27 Gorsuch AN, Lister J., Dean BM et al. Evidence for a long prediabetic period in type 1 (insulin-dependent) diabetes mellitus. Lancet 1981; ii: 1363– 5. 28 Bottazzo GF, Florin-Christensen A., Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974; ii: 1279– 83. 29 Groop LC, Bottazzo GF, Doniach D. Islet cell antibodies identify latent type 1 diabetes in patients aged 35–75 years at diagnosis. Diabetes 1986; 35: 237– 41. 30 Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PGF, Gamble DR. In situ characterization of autoimmune phenomena and expression of HLA class II molecules in the pancreas in diabetic insulitis. N Eng J Med 1985; 313: 353– 60. 31 Nayak RC, Omar MAK, Rabizadeh A., Srikanta S., Eisenbarth GS. Cytoplasmic' islet cell antibodies: evidence that the target antigen is a sialoglycoconjugate. Diabetes 1985; 34: 617– 19. 32 Bruining GJ, Molenaar JM, Grobbe DE et al. Ten-year follow-up study of islet cell antibodies and childhood diabetes mellitus. Lancet 1989; 1: 1100– 3. 33 Mandrup-Poulsen T., Nerup J., Stiller CR, Marner B., Bille G., Heinrichs D., Martell R., Dupre J., Keown PA, Jenner MR, Rodger NW, Wolfe B., Graffenried BV, Binder C. Disappearance of islet cell cytoplasmic antibodies in cyclosporin-treated insulin-dependent diabetics. Lancet 1985; i: 599– 602. 34 Harrison LC, Campbell IL, Colman PG, Chosich N., Kay TWH, Tait B., Bartholomeusz RK, de Aizpurua H., Joseph JL, Chu S., Kielczynski WE. Type 1 diabetes: Immunopatho-logy and Immunotherapy. Adv Endocrinol Metab 1990; 1: 35– 94. 35 Sibley RK, Sutherland DER, Goetz F., Michael AF. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest 1985; 53: 132– 44. 36 Palmer JP, Asplin CM, Clemens P. et al. Insulin antibodies in insulin dependent diabetes before insulin treatment. Science 1983; 222: 1337– 9. 37 Wilkin T., Hoskins PJ, Armitage M. et al. Value of insulin autoantibodies as serum markers for insulin dependent diabetes mellitus. Lancet 1985; i: 480– 2. 38 Arslanian SA, Becker DJ, Ralrin B. et al. Correlates of insulin antibodies in newly diagnosed children with insulin-dependent diabetes before insulin therapy. Diabetes 1985; 34: 926– 30. 39 MacEvoy RC, Witt E., Ginsberg-Fellner F. et al. Anti-insulin antibodies in children with type 1 diabetes mellitus. Diabetes 1986; 35: 634– 41. 40 Dean BM, Becker F., McNally JM et al. Insulin autoantibodies in the prediabetic period: correlation with islet cell antibodies and development of diabetes. Diabetologia 1986; 29: 339– 42. 41 Atkinson MA, MacLaren NK, Riley WJ et al. Are insulin autoantibodies markers for insulin-dependent diabetes mellitus Diabetes 1986; 35: 894– 8. 42 Baekkeskov S., Landin M., Kristensen JK et al. Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987; 79: 926– 34. 43 Riley WJ, MacLaren NK, Spillar RP et al. The use of islet-cell autoantibodies in identifying 'prediabetes'. In Z. Larkins, P. Zimmet, D. Chrisholm (eds): Diabetes 1988. Amsterdam , Netherlands , Elsevier, 1989; 263– 7. 44 Baekkeskov S., Nielson JH, Marner B., Bilde T., Ludvigsson J., Lernmark A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate specific human pancreatic islet proteins. Nature 1982; 298: 167– 9. 45 Baekkeskov S., Dyrberg T., Lernmark A. Autoantibodies to a 64-Kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science 1984; 224: 1348– 50. 46 Atkinson MA, MacLaren NK. Autoantibodies in non-obese diabetic mice immunoprecipitate 64,000-Mr islet antigen. Diabetes 1988; 37: 1587– 90. 47 Atkinson MA, MacLaren NK, Scharp DW, Lacy PE, Riley WJ. 64000 Mr autoantibodies as predictors of insulin-dependent diabetes. Lancet 1990; 335: 1357– 60. 48 Baekkeskov S., Aanstoot H-J, Christgau S. et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 1990; 347: 151– 6. 49 Pak Cy, Cha CY, Rajotte RV, McArthur RG, Yoon JW. Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet-cell autoantibody. Diabetologia 1990; 33: 569– 72. 50 Ko IY, Ihm SH, Yoon JW. Studies on autoimmunity for the initiation β-cell destruction VIII: Pancreatic β-cell dependent autoantibody to a 38 kilodalton protein precedes the clinical onset of diabetes in BB rats. Diabetologia 1991; 34: 548– 54. 51 Jones DB, Hunter NR, Duff GW. Heat-shock protein 65 as a beta cell antigen of insulin-dependent diabetes. Lancet 1990; 336: 583– 5. 52 Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965; 14: 619– 63. 53 Hanafusa T., Miyazaki A., Miyagawa J. et al. Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients. Diabetologia 1990; 33: 105– 11. 54 Ogawa M., Maruyuama T., Hasegawa T. et al. The inhibitory effect of neonatal thymectomy on the incidence of insulitis in non-obese (NOD) mice. Biomed Res 1985; 6: 103– 5. 55 Like AA, Kislauskis E., Williams RM, Rossini AA. Neonatal thymectomy prevents spontaneous diabetes mellitus in BB/W rat. Science 1982; 216: 644. 56 Ikehara S., Ohtsuki H., Good RA et al. Prevention of type 1 diabetes in nonobese diabetic (NOD) mice by allogeneic bone marrow transplantation. Proc Natl Acad Sci USA 1985; 82: 7743– 7. 57 Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from non-obese diabetic (NOD) mice. Diabetes 1986; 35: 855– 60. 58 Koevary S., Rossini A., Stoller W., Chick W., Williams RM. Passive transfer of diabetes in the BB/W rat. Science 1983; 220: 727– 8. 59 Bendelac AC, Carnaud C., Boitard C., Bach F-C. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both Lyt2+ and L3T4+ T cells. J ExpMed 1987; 166: 823. 60 Miller BJ, Appel MC, O'Neil JJ, Wicker LS. Both the Lyt-2 + and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 1988; 140: 52– 8. 61 Charlton B., Mandel TE. Progression fron insulitis to β-cell destruction in NOD mouse requires L3T4+ T-lymphocytes. Diabetes 1988; 37: 1108– 12. 62 Hanafusa T., Sigihara S., Fujino-Kurihara H. et al. Induction of insulitis by adoptive transfer with L3T4 + Lyt2- T-lymphocytes in T-lymphocyte depleted NOD-mice. Diabetes 1988; 37: 204– 8. 63 Dayer-Metroz M-D, Kimoto M., Izui S., Vassalli P., Renold AE. Effect of helper and/or cytotoxic T-lymphocyte depletion on low-dose streptozocin-induced diabetes in C57BL/6J mice. Diabetes 1988; 37: 1082– 9. 64 Wang Y., Hao L., Gill RG, Lafferty K.J. Autoimune diabetes in NOD mouse is L3T4 T-lymphocyte dependent. Diabetes 1987; 36: 535. 65 Koike T., Hoh Y., Ishi M. Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice. Diabetes 1987; 36: 539– 41. 66 Wang Y., Pontesilli O., Gill RG, La Rosa FG, Lafferty K. The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneous diabetic mice. Proc Natl Acad Sci USA 1991; 88: 527– 31. 67 Prowse SJ, Bellgrau D., Lafferty K. Islet allografts are destroyed by disease occurrence in the spontaneously diabetic BB rat. Diabetes 1986; 35: 110– 14. 68 Metroz-Dayer M-D, Mouland A., Brideau C., Duhamel D., Poussier P. Adoptive transfer of diabetes in BB rats induced by CD4 T lymphocytes. Diabetes 1990; 39: 928– 32. 69 Ohashi PS, Oehen S., Buerki K., Pircher H., Ohashi CT, Odermatt B., Malissen B., Zinkernagel RM, Hengartner H. Ablation of 'tolerance' and induction of diabetes by virus infection in viral transgenic mice. Cell 1991; 65: 305– 17. 70 MacCuish AC, Jordan J., Campbell CJ, Duncan LPJ, Irvine WJ. Cell-mediated immunity in diabetes mellitus: lymphocyte transformation by insulin and insulin fragments in insulin-treated and newly-diagnosed diabetics. Diabetes 1975; 24: 36– 43. 71 Naquet P., Ellis J., Tibensky D., Kennshole A., Singh B., Hodges R., Delovitch TL. T cell autoreactivity to insulin in diabetic and related non-diabetic individuals. J Immunol 1988; 140: 2569– 78. 72 Prud'homme GJ, Fuks A., Guttmann RD, Colle E. T cell hybrids with specificity for islet cell antigens. J Immunol 1986; 136: 1535– 6. 73 de Berardinis P., Londei M., James RFL, Lake SP, Wise PH, Feldmann M. Do CD4-positive cytotoxic T cells damage islet β cells in type 1 diabetes Lancet 1988; i: 823– 5. 74 Haskins K., Portas M., Bradley B., Wegmann D., Lafferty K. T-lymphocyte clone specific for pancreatic islet antigen. Diabetes 1988; 37: 1444– 8. 75 Haskins K., Portas M., Bergman B., Lafferty K., Bradley B. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc Natl Acad Sci USA 1989; 86: 8000– 4. 76 Haskins K., McDuffie M. Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science 1990; 249: 1433– 6. 77 Nagata M., Yokono K., Hayakawa M. et al. Destruction of pancreatic islet cells by cytotoxic T lymphocytes in nonobese mice. J Immunol 1989; 143: 1155– 62. 78 Nagata M., Yokono K., Hatamori N., Shii K., Baba S. The presence of splenic T cells specific for islet cell antigens in nonobese diabetic mice. Clin Immunol Pathol 1989; 53: 171– 80. 79 Reich E-P, Sherwin RS, Kanagawa O., Janeway CA. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature 1989; 341: 326– 8; (correction) Nature 1991; 352:88. 80 Roep BO, Arden SD, de Vries RRP, Hutton JC. T-cell clones from a type 1 diabetes patient respond to insulin-secretory granule proteins. Nature 1990; 343: 632– 34. 81 Harrison LC, de Aizpurua H., Loudovaris T. et al. Reactivity to human islets and pig-proislets by peripheral blood mono-nuclear cells from subjects with preclinical and clinical insulin-dependent diabetes. Diabetes 1991; 40: 1128– 33. 82 Diaz JL, Ways J., Hammonds P. T-lymphocyte lines specific for glutamic acid decarboxylase (GAD) the 64K β-cell antigen in IDDM. Diabetes 1992; 41: 118– 21. 83 Atkinson MA, Kaufman DL, Campbell L., Gibbs KA, Shah SC, Bu D-F, Erlander MG, Tobin AJ, McLaren NK. Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 1992; 339: 458– 9. 84 Elias D., Markovits D., Reshef T., van der Zee R., Cohen IR. Induction and therapy of autoimmune diabetes in the nonobese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 1990; 87: 1576– 80. 85 Candeias S., Katz J., Benoist C., Mathis D., Haskins K. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc Natl Acad Sci USA 1991; 88: 6167– 70. 86 Waters SH, O'Neil JJ, Melican DT, Appel MC. Multiple TCR Vβ usage by infiltrates of young NOD mouse islets of Langer-hans. A polymerase chain reaction analysis. Diabetes 1992; 41: 308– 12. 87 Maeda T., Sumida T., Kurasawa K. et al. T-lymphocyte receptor repertoire of infiltrating T-lymphocytes into NOD mouse pancreas. Diabetes 1991; 40: 1580– 5. 88 Roep BO, Kalian AA, de Vries RRP. B-cell antigen specific lysis of marcrophages by CD4 T-cell clones from newly diagnosed type 1 diabetes patient: A putative mechanism of T-cell mediated autoimmune islet-cell destruction. Diabetes (in press) (1992). 89 Roussel B., Vialettes B., Bernier-Valentin F., Vague P., Beylot M., Mornex R. Anti-tubulin antibodies in recent onset type 1 (insulin-dependent) diabetes mellitus: comparison with islet cell antibodies. Diabetologia 1984; 27: 427– 32. 90 Gregor I., Iberg N., Berger W., Fluckinger R. Albumin-directed antibodies in diabetes: demonstration of human serum albumin-directed IgM autoantibodies. Diabetologia 1986; 29: 481– 4. 91 DiMario U., Dotta F., Crista L. et al. Circulating anti-immuno-globulin antibodies in recent onset type 1 diabetes patients. Diabetes 1988; 37: 462– 6. 92 Res PC, Telgt D., van Laar JM, Pool MO, Breed Veld FC, de Vries RR. High antigen reactivity in mononuclear cells from sites of chronic inflammation. Lancet 1990; 336: 1406– 8. 93 Parham P. Intolerable secretion in tolerant transgenic mice. Nature 1988; 333: 500– 3. 94 Editorial The 64K question in diabetes. Lancet 1990; 336: 597– 8. 95 Buschard K. For debate: The functional state of the beta cells in the pathogenesis of insulin-dependent diabetes mellitus. Autoimmunity 1991; 10: 65– 70. 96 Christie MR, Vohra G., Champagne P., Daneman D., Delovitch TL. Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment. J Exp Med 1990; 172: 789– 94. 97 Robertson RB. Perspective in diabetes: Pancreas transplantation in humans with diabetes mellitus. Diabetes 1991; 40: 1085– 9. 98 Jung PJ, Merrell RC. Update on pancreatic islet transplantation. Sem Surg Oncol 1990; 6: 122– 5. 99 Warnock GL, Kneteman NM, Ryan E., Seelis REA et al. Normoglycaemia after transplantation of freshly isolated and crypreserved pancreatic islets in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1991; 34: 55– 8. 100 Warnock GL, Seelis REA, Kneteman NM, Rajotte RV. Studies of the isolation and transplantation of purified islet in adult humans. Transpl Proc 1991; 23: 787– 8. 101 Orloff MJ, Greenleaf GE, Urban P., Girard B. Lifelong reversal of the metabolic abnormalities of advanced diabetes in rats by whole pancreas transplantation. Transplantation 1986; 41: 556– 64. 102 Kemp CB, Night MJ, Sharp DW, Lacy PE, Ballinger WF. Transplantation of isolated pancreatic islets into the portal vein of diabetic rats. Nature (Lond.) 1973; 244: 447– 9. 103 Brown J., Molnar FG, Calrck W., Mullen Y. Control of experimental diabetes mellitus of rats by transplantation of fetal pancreases. Science 1974; 184: 1377– 9. 104 Liu X., Federlin KF, Bretzel RG, Hering BJ, Brendel MD. Persistent reversal of diabetes by transplantation of fetal pig proislets into nude mice. Diabetes 1991; 40: 858– 66. 105 Pipeleers DG, Pipeleers MA, Hannaert JC et al. Transplantation of purified islet cells in diabetic rats. I: Standardization of islet cell grafts. Diabetes 1991; 40: 908– 19. 106 Kedinger M., Haffen K., Grenier J., Elroy R. In vitro culture reduces immunogenecity of pancreatic endocrine islets. Nature (Lond.) 1977; 270: 736– 8. 107 Faustman D., Hauptfeld V., Lacy P., Davie J. Prolongation of murine islet allograft survival by treatment of islets with antibody directed to la determinants. Proc Natl Acad Sci USA 1981; 78: 5156– 9. 108 Faustman DL, Steinman RM, Gebel HM, Hauptfeld V., Davie JM, Lacy PE. Prevention of rejection of murine islet allograft by treament with anti-dendritic antibody. Proc Natl Acad Sci USA 1984; 81: 3864– 8. 109 Faustman D., Coe C. Prevention of xenograft rejection by masking donor HLA class I antigens. Science 1991; 252: 1700– 2. 110 Lafferty KJ, Prowse SJ, Simeonovics CJ, Warren H. Immuno-biology of tissue transplantation: a return to the passenger leucocyte concept. Ann Rev Immunol 1983; 1: 143– 59. 111 Lau H., Reemtsma K., Hardy MA. Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft. Science 1984; 223: 607– 9. 112 Pipeleers DG, Pipeleers-Marichal M., Vanbrabandt B., Duys S. Transplantation of purified islet cells in diabetic rats. II: Immunogenecity of allografted β-cells. Diabetes 1991; 40: 920– 30. 113 Pipeleers-Marichal M., Ling ZD, Teng H., Pipeleers DG. Transplantation of purified islet cells in diabetic rats. III: Immunosuppressive effect of cyclosporin. Diabetes 1991; 40: 931– 8. 114 Scharp DW, Lacy PE, Santiago JV et al. Insulin independence after islet transplantation into type 1 diabetic patient. Diabetes 1990; 39: 515– 18. 115 Warnock GL, Kneteman NM, Ryan EA, Evans MG et al. Continued function of pancreatic islets after transplantation in type 1 diabetes. Lancet (letter) 1989; ii: 570– 2. 116 Weber CJ, Zabinski S., Koschitzky T. et al. The role of CD4 + helper T cells in the destruction of microencapsulated islet xenografts in NOD mice. Transplantation 1990; 49: 396– 404. 117 Mazaheri R., Atkinson P., Stiller C., Dupre J., Vose J., O'Shea G. Transplantation of encapsulated allogeneic islets into diabetic BB/W Rats. Effects of immunosuppression. Transplantation 1991; 51: 750– 4. 118 Fan MY, Lum ZP, Fu XW, Levesque L., Tai IT, Sun AM. Reversal of diabetes in BB rats by transplantation of encapsulated pancreatic islets. Diabetes 1990; 39: 519– 22. 119 Acha-Orbea H., Mitchell DJ, Timmermann L., Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988; 54: 263– 73. 120 Elliot RB, Crossley JR, Berryman CC et al. Partial preservation of β-cell function in children with diabetes. Lancet 1981; ii: 1– 4. 121 Harrison LC, Colman PG, Dean B. et al. Increase in remission rate in newly diagnosed type I diabetic subjects treated with azathioprine. Diabetes 1985; 34: 1306– 8. 122 Silverstein J., Maclaren N., Riley W., Spillar R., Radjenovic D., Johnson S. Immunosuppression with azathioprine and predni-sone in recent-onset insulin-dependent diabetes mellitus. N Engl J Med 1988; 319: 599– 604. 123 Stiller CR, Dupre J., Gent M. et al. Effects of cyclosporin immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 1984; 223: 1362– 7. 124 Canadian-European Diabetes Study Group Cyclosporin-induced remission of IDDM after early intervention: Association of 1 year of cyclosporin treatment with enhanced insulin secretion. Diabetes 1988; 37: 1574– 82. 125 Bougneres PF, Carel JC, Castano L. et al. Factors associated with early remission of type 1 diabetes in children treated with cyclosporin. N Engl J Med 1990; 318: 663– 70. 126 Oates JA, Wood AAJ, Kahan BD. Drug therapy. Cyclosporin. NEngJMed 1989; 321: 1725– 38. 127 Hahn HJ, Lucke S., Kloting I., Volk H., Baehr RV, Diamanstein T. Curing BB rats of freshly manifested diabetes by short-term treatment with a monoclonal anti-interleukin-2 receptor antibody and subtherapeutic dose of cyclosporin A. Eur J Immunol 1987; 17: 1075– 8. 128 Benjamin RJ, Waldmann H. Induction of tolerance by monoclonal antibody therapy. Nature 1986: 320: 449– 51. 129 Like AA, Biron CA, Werniger EJ, Byman K., Sroczynski E., Guberski DL. Prevention of diabetes in biobreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes of natural killer cells. J Exp Med 1986; 164: 1145– 59. 130 Shizuru JA, Taylor-Edwards C., Banks BA, Gregory AK, Fathman CG. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 1988; 240: 659– 62. 131 Charlton B., Bacelj A., Mandel TE. Administration of silica particles or anti-Lyt2 antibody prevents β-cell destruction in NOD mice given phosphamide. Diabetes 1988: 37: 930– 5. 132 Boitard C., Bendeloc A., Richard MF et al. Prevention of diabetes in non-obese diabetic mice by anti I-A monoclonal antibodies: transfer of protection by splenic T cells. Proc Natl Acad Sci USA 1988; 85: 9719– 23. 133 Kelley VE, Gaulton GN, Hattori M. et al. Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis. J Immunol 1988; 140: 59– 61. 134 Campbell IL, Cutri A., Wilson A., Harrison LC. Evidence of IL-6 production by and effects on the pancreatic beta-cell. J Immunol 1989; 143: 1188– 91. 135 Campbell IL, Kay TW, Oxbrow L., Harrison LC. Essential role for interferogamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J Clin Invest 1991; 87: 739– 42. 136 Cohen IR. T lymphocyte vaccination against autoimmune diseases. In: IR Cohen ed. Perspectives on Autoimmunity. Boca Raton , Florida : CRC Press, 1988: 210– 17. 137 Cohen IR, Weiner HL. T cell vaccination. Immunol Today 1988; 9: 332– 5. 138 Adorini L., Barnaba V., Bona C. et al. New perspectives on immunointervention in autoimmune diseases. Immunol Today 1990; 11: 383– 6. 139 Vandenbark AA, Hashim G., Offner H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental allergic encephalomyelitis. Nature 1989; 341: 541– 4. 140 Howell MD, Winters ST, Olee T., Powell HC, Carlo DJ, Brostoff SW: Vaccination against experimental allergic encephalomyelitis with T-cell receptor peptides Science 1989; 246: 668– 70. 141 Offner H., Hashim GA, Vandenbark AA. T cell receptor peptide therapy triggers autoregulation of experimental encephalomye-litis. Science 1990; 251: 430– 2. 142 Desquenne-Clark L., Esch TR, Otvos L., Heber-Katz E. T-cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis. Proc Natl Acad Sci USA 1991; 88: 7219– 23. 143 Oksenberg JR, Stuart S., Begovich AB et al. Limited heterogeneity of rearranged T-cell receptor V Ipha transcripts in brains of multiple sclerosis patients. Nature 1990; 345: 344– 6. 144 Dayan CM, Londei M., Corcoran AE et al. Autoantigen recognition by thyroid-infiltrating T cells in Graves disease. Proc Natl Acad Sci USA 1991; 88: 7415– 19. 145 Janeway CA. Immunotherapy by peptides Nature 1989; 341: 482– 3. 146 Wraith DC, Smilec DE, Mitchell DJ, Steinman L., McDevitt HO. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide mediated immunotherapy. Cell 1989; 59: 247– 55. 147 Thomsen HSG, Staines NA. Could specific oral tolerance be a therapy in autoimmune disease Immunol Today 1990; 11: 396– 9. 148 Pozzilli P., Kolb H. Immunotherapy in type 1 diabetes: present status. Immunol Today 1989; 10: 321– 2. 149 Rossini AA, Slavin S., Woda BA, Geisberg M., Like AA, Mordes JP. Total lymphoid irradiation prevents diabetes mellitus in biobreeding/Worcester rats. Diabetes 1984; 33: 543– 7. 150 Boitard C., Debray-Sachs M., Poulard A., Assan R., Hamburger J. Lymphocytes from diabetics suppress insulin release in vitro. Diabetologia 1981; 21: 41– 6. 151 Boitard C., Chatenoud LM, Debray-Sachs M. In vitro inhibition of pancreatic beta-cell function by lymphocytes from diabetics with associated autoimmune diseases: a T-cell phenomenon. J Immunol 1982: 129; 2529– 31. 152 Boitard C., Yasunami R., Dardenne M., Bach J-F. T-cell mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J Exp Med 1989; 169: 1669– 80. Citing Literature Volume22, Issue11November 1992Pages 697-711 ReferencesRelatedInformation
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