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A Symmetrical Fluorous Dendron‐Cyanine Dye‐Conjugated Bimodal Nanoprobe for Quantitative 19 F MRI and NIR Fluorescence Bioimaging

2014; Wiley; Volume: 3; Issue: 8 Linguagem: Inglês

10.1002/adhm.201400088

2192-2659

Zhe Wang, Xuyi Yue, Yu Wang, Chunqi Qian, Peng Huang, Marty Lizak, Gang Niu, Fu Wang, Pengfei Rong, Dale O. Kiesewetter, Ying Ma, Xiaohong Chen,

Lanthanide and Transition Metal Complexes

19 F MRI and optical imaging are two powerful noninvasive molecular imaging modalities in biomedical applications. 19 F MRI has great potential for high resolution in vivo imaging, while fluorescent probes enable ultracontrast cellular/tissue imaging with high accuracy and sensitivity. A bimodal nanoprobe is developed, integrating the merits of 19 F MRI and fluorescence imaging into a single synthetic molecule, which is further engineered into nanoprobe, by addressing shortcomings of conventional contrast agents to explore the quantitative 19 F MRI and fluorescence imaging and cell tracking. Results show that this bimodal imaging nanoprobe presents high correlation of 19 F MR signal and NIR fluorescence intensity in vitro and in vivo. Additionally, this nanoprobe enables quantitative 19 F MR analysis, confirmed by a complementary fluorescence analysis. This unique feature can hardly be obtained by traditional 19 F MRI contrast agents. It is envisioned that this nanoprobe can hold great potential for quantitative and sensitive multi‐modal molecular imaging.