Molecular dynamics simulations of G-DNA and perspectives on the simulation of nucleic acid structures
2012; Elsevier BV; Volume: 57; Issue: 1 Linguagem: Inglês
10.1016/j.ymeth.2012.04.005
ISSN1095-9130
AutoresJiřı́ Šponer, Xiaohui Cang, Thomas E. Cheatham,
Tópico(s)RNA and protein synthesis mechanisms
ResumoThe article reviews the application of biomolecular simulation methods to understand the structure, dynamics and interactions of nucleic acids with a focus on explicit solvent molecular dynamics simulations of guanine quadruplex (G-DNA and G-RNA) molecules. While primarily dealing with these exciting and highly relevant four-stranded systems, where recent and past simulations have provided several interesting results and novel insight into G-DNA structure, the review provides some general perspectives on the applicability of the simulation techniques to nucleic acids.
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