Abnormal cobalamin-dependent transmethylation in AIDS-associated myelopathy
2002; Lippincott Williams & Wilkins; Volume: 58; Issue: 5 Linguagem: Inglês
10.1212/wnl.58.5.730
ISSN1526-632X
AutoresAlessandro Di Rocco, Teodoro Bottiglieri, P. Werner, Alessandro Geraci, David M. Simpson, James Godbold, Susan Morgello,
Tópico(s)Neurogenetic and Muscular Disorders Research
ResumoBackground: White matter vacuolization of the spinal cord is common in patients with AIDS and may lead to clinical manifestations of myelopathy. The pathogenesis of AIDS-associated myelopathy (AM) is unknown and may be related to metabolic abnormalities rather than to direct HIV infection. The striking pathologic similarity between AM and the vacuolar myelopathy associated with vitamin B12 deficiency suggests that abnormal metabolism of the B12-dependent transmethylation pathway may be important in the pathogenesis of AM.
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