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Effects of exercise training on neurovascular responses during handgrip exercise in heart failure patients

2010; Elsevier BV; Volume: 146; Issue: 1 Linguagem: Inglês

10.1016/j.ijcard.2010.09.091

1874-1754

Luísa Soares‐Miranda, Fabio G.M. Franco, Fabiana Roveda, Daniel Godoy Martinêz, Maria Urbana Pinto Brandão Rondon, Jorge Mota, Patrı́cia C. Brum, Lígia M. Antunes‐Correa, Thais S. Nobre, Antônio Carlos Pereira Barretto, Holly R. Middlekauff, Carlos Eduardo Negrão,

Heart Failure Treatment and Management

Exaggerated central sympathetic outflow typifies chronic heart failure (HF) [ [1] Negrao C.E. Middlekauff H.R. Adaptations in autonomic function during exercise training in heart failure. Heart Fail Rev. 2008; 13: 51-60 Crossref PubMed Scopus (79) Google Scholar ]. Augmented plasma catecholamine levels, norepinephrine spillover and muscle sympathetic nerve activity (MSNA) have been demonstrated in HF patients [ 2 Cohn J.N. Levine T.B. Olivari M.T. et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984; 311: 819-823 Crossref PubMed Scopus (2860) Google Scholar , 3 Negrao C.E. Rondon M.U. Tinucci T. et al. Abnormal neurovascular control during exercise is linked to heart failure severity. Am J Physiol Heart Circ Physiol. 2001; 280: H1286-H1292 Crossref PubMed Google Scholar ]. In addition, HF patients have reduced skeletal muscle blood flow (FBF) [ 4 Barretto A.C. Santos A.C. Munhoz R. et al. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Int J Cardiol. 2009; 135: 302-307 Abstract Full Text Full Text PDF PubMed Scopus (226) Google Scholar , 5 Middlekauff H.R. Nitzsche E.U. Hoh C.K. et al. Exaggerated renal vasoconstriction during exercise in heart failure patients. Circulation. 2000; 101: 784-789 Crossref PubMed Scopus (83) Google Scholar ], which may explain, at least in part, the skeletal myopathy and exercise intolerance in HF patients [ [1] Negrao C.E. Middlekauff H.R. Adaptations in autonomic function during exercise training in heart failure. Heart Fail Rev. 2008; 13: 51-60 Crossref PubMed Scopus (79) Google Scholar ].