Artigo Revisado por pares

Histiocytosis X in an elderly patient. Ultrastructure and immunocytochemistry after PUVA photochemotherapy

1988; Oxford University Press; Volume: 119; Issue: 3 Linguagem: Inglês

10.1111/j.1365-2133.1988.tb03233.x

ISSN

1365-2133

Autores

Christine Neumann, G. Kolde, Gisela Bonsmann,

Tópico(s)

Eosinophilic Disorders and Syndromes

Resumo

The clinical features of a 76-year-old man with histiocytosis X of the Letterer-Siwe type, with extensive skin involvement, are described. The patient's lesions responded dramatically to PUVA-photochemotherapy. Light microscopic, immunocytochemical and immunoelectron microscopic findings, before and after PUVA, are reported. Birbeck granules in phagolysosomes of dermal macrophages indicated uptake of destroyed HX cells. Residual HX cells in the skin and HX cells in a recurring lesion expressed the same membrane antigens as in the primary lesions.

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