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Lambert-Eaton myasthenic syndrome with ophthalmoparesis and pseudoblepharospasm

1999; Wiley; Volume: 22; Issue: 12 Linguagem: Inglês

10.1002/(sici)1097-4598(199912)22

1097-4598

Naomi Kanzato, Masakatsu Motomura, Masahito Suehara, Kimiyosi Arimura,

Peripheral Neuropathies and Disorders

Muscle & NerveVolume 22, Issue 12 p. 1727-1730 Case of the Month Lambert–Eaton myasthenic syndrome with ophthalmoparesis and pseudoblepharospasm Naomi Kanzato MD, Corresponding Author Naomi Kanzato MD Department of Neurology, National Okinawa Hospital, Ganeko 3-20-14, Ginowan-shi, Okinawa 901-2214, JapanDepartment of Neurology, National Okinawa Hospital, Ganeko 3-20-14, Ginowan-shi, Okinawa 901-2214, JapanSearch for more papers by this authorMasakatsu Motomura MD, Masakatsu Motomura MD Third Department of Internal Medicine, Kagoshima University, Kagoshima, JapanSearch for more papers by this authorMasahito Suehara MD, Masahito Suehara MD Department of Neurology, National Okinawa Hospital, Ganeko 3-20-14, Ginowan-shi, Okinawa 901-2214, JapanSearch for more papers by this authorKimiyosi Arimura MD, Kimiyosi Arimura MD First Department of Internal Medicine, Nagasaki University, Nagasaki, JapanSearch for more papers by this author Naomi Kanzato MD, Corresponding Author Naomi Kanzato MD Department of Neurology, National Okinawa Hospital, Ganeko 3-20-14, Ginowan-shi, Okinawa 901-2214, JapanDepartment of Neurology, National Okinawa Hospital, Ganeko 3-20-14, Ginowan-shi, Okinawa 901-2214, JapanSearch for more papers by this authorMasakatsu Motomura MD, Masakatsu Motomura MD Third Department of Internal Medicine, Kagoshima University, Kagoshima, JapanSearch for more papers by this authorMasahito Suehara MD, Masahito Suehara MD Department of Neurology, National Okinawa Hospital, Ganeko 3-20-14, Ginowan-shi, Okinawa 901-2214, JapanSearch for more papers by this authorKimiyosi Arimura MD, Kimiyosi Arimura MD First Department of Internal Medicine, Nagasaki University, Nagasaki, JapanSearch for more papers by this author First published: 17 November 1999 https://doi.org/10.1002/(SICI)1097-4598(199912)22:12 3.0.CO;2-KCitations: 24AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract We report a patient initially diagnosed as having ocular myasthenia gravis who showed progressive ophthalmoparesis and pseudoblepharospasm together with positive acetylcholine receptor antibodies. Repeated evaluation with high-frequency repetitive stimulation revealed an incremental response and elevated titers of antibodies against presynaptic calcium channels, confirming Lambert–Eaton myasthenic syndrome. Systemic evaluation revealed no malignant neoplasm but revealed euthyroid Hashimoto's disease. Immunomodulative therapy including plasma exchange and administration of an immunosuppressent (azathioprine) combined with a potassium-channel blocker (3,4-diaminopyridine) reduced the ocular abnormalities. We conclude that the ocular manifestations in this patient were probably caused by Lambert–Eaton myasthenic syndrome. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1727–1730, 1999 Citing Literature Volume22, Issue12December 1999Pages 1727-1730 RelatedInformation