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Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma

2014; Elsevier BV; Volume: 125; Issue: 7 Linguagem: Inglês

10.1182/blood-2014-04-566778

1528-0020

Javeed Iqbal, Yulei Shen, Xin Huang, Yanyan Liu, Laura Wake, Cuiling Liu, Karen Deffenbacher, Cynthia M. Lachel, 王超 Wang Chao, Joseph Rohr, Shuangping Guo, Lynette M. Smith, George W. Wright, Sharathkumar Bhagavathi, Karen Dybkær, Kai Fu, Timothy C. Greiner, Julie M. Vose, Elaine S. Jaffe, Lisa M. Rimsza, Andreas Rosenwald, German Ott, Jan Delabie, Elı́as Campo, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, Jamés O. Armitage, Dennis D. Weisenburger, Louis M. Staudt, Randy D. Gascoyne, Timothy W. McKeithan, Wing C. Chan,

RNA modifications and cancer

Key Points Well-defined miRNA signatures for normal B-cell subsets and their malignant counterparts including BL and DLBCL subgroups were identified. In DLBCL, miRNA-155 expression is associated with R-CHOP resistance, but in vitro sensitivity to AKT pathway inhibition.