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Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga

2009; American Chemical Society; Volume: 73; Issue: 3 Linguagem: Inglês

10.1021/np900644x

1520-6025

Maria A. R. Serrano, Marcos Pivatto, Welington Francisco, Amanda Danuello, Luís Octávio Regasini, Elaine Monteiro Cardoso Lopes, Márcia Nasser Lopes, Maria Cláudia Marx Young, Vanderlan da Silva Bolzani,

Allelopathy and phytotoxic interactions

Two unusual pyridine alkaloids, 7′-multijuguinone (1) and 12′-hydroxy-7′-multijuguinone (2), were isolated from the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established on the basis of spectroscopic data interpretation. Compounds 1 and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison with the standard compound physostigmine.