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HIV-infected pregnant women have greater adherence with antiretroviral drugs than non-pregnant women

2007; SAGE Publishing; Volume: 18; Issue: 1 Linguagem: Inglês

10.1258/095646207779949808

1758-1052

Maria José Rodrigues Vaz, Sônia Maria Oliveira de Barros, Ricardo Palácios, Jorge Figueiredo Senise, L Lunardi, Abês Mahmed Amed, Adauto Castelo,

Syphilis Diagnosis and Treatment

The objective of the study was to evaluate the influence of pregnancy on the level of adherence with antiretroviral (ARV) drugs, in a prospective cohort of 72 pregnant women and 79 non-pregnant women. Adherence was measured by pill counting and self-reporting. Women were deemed adherent if 95% or more of all ARV had been taken as prescribed, in two occasions. According to pill counting, 43.1 and 17.7% of pregnant and non-pregnant women, respectively, met the criteria of adherence ( P = 0.001); in the postpartum, adherence declined to 20.6% ( P = 0.002). In both groups, adherence rates by self-reporting were significantly higher as compared with pill counting ( P = 0.001). In multivariate regression analysis, age >29 years (odds ratio [OR] 3.58, confidence interval [CI] 95% 0.10–0.75, P = 0.011), mean number of pills/day <6 (OR 2.53, CI 95% 1.07–6.01, P = 0.035), and being pregnant (OR 3.33, CI 95% 1.36–8.13, P = 0.008) were independently associated to greater adherence.