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Clinical and Biochemical Presentation of Gouty Diathesis: Comparison of Uric Acid Versus Pure Calcium Stone Formation

1995; Lippincott Williams & Wilkins; Volume: 154; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(01)66743-0

1527-3792

Joseph Khatchadourian, Glenn M. Preminger, Peggy A. Whitson, Beverley Adams‐Huet, Charles Y.C. Pak,

Muscle and Compartmental Disorders

No AccessJournal of UrologyClinical Urology: Original Article1 Nov 1995Clinical and Biochemical Presentation of Gouty Diathesis: Comparison of Uric Acid Versus Pure Calcium Stone Formation Joseph Khatchadourian, Glenn M. Preminger, Peggy A. Whitson, Beverley Adams-Huet, and Charles Y.C. Pak Joseph KhatchadourianJoseph Khatchadourian , Glenn M. PremingerGlenn M. Preminger , Peggy A. WhitsonPeggy A. Whitson , Beverley Adams-HuetBeverley Adams-Huet , and Charles Y.C. PakCharles Y.C. Pak View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66743-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We compared gouty diathesis with uric acid versus calcium stones. Materials and Methods: We retrospectively reviewed clinical and laboratory data from 95 gouty diathesis patients (28 with uric acid and 67 with calcium stones) and 99 normal subjects. Results: Of the gouty diathesis patients gouty arthritis was present in 21 percent of those with uric acid and 12 percent of those with calcium stones. Hyperuricemia developed in 43 percent of those with uric acid and 27 percent of those with calcium stones, and 2 percent of controls. Urinary pH was independent of the net gastrointestinal absorption of alkali in the gouty diathesis groups. Urinary pH and citrate increased after potassium citrate treatment. Conclusions: The characteristic features of primary gout were present in both gouty diathesis groups and both are responsive to treatment. References 1 : Uric acid nephrolithiasis in gout: predisposing factors. Ann. Intern. Med.1967; 67: 1133. Crossref, Medline, Google Scholar 2 : Uric acid nephrolithiasis. In: Urolithiasis: A Medical and Surgical Reference. Edited by . Philadelphia: W. B. Saunders Co.1990: 105. chapt. 7. Google Scholar 3 : Stability of first dissociable proton of uric acid. J. Chem. Eng. Data1974; 19: 94. 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Google Scholar Center for Mineral Metabolism, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAssimos D (2014) Re: Renal Ammonium Excretion after an Acute Acid Load: Blunted Response in Uric Acid Stone Formers but Not in Patients with Type 2 DiabetesJournal of Urology, VOL. 191, NO. 4, (994-995), Online publication date: 1-Apr-2014.Marchini G, Sarkissian C, Tian D, Gebreselassie S and Monga M (2012) Gout, Stone Composition and Urinary Stone Risk: A Matched Case Comparative StudyJournal of Urology, VOL. 189, NO. 4, (1334-1339), Online publication date: 1-Apr-2013.MALONEY M, SPRINGHART W, EKERUO W, YOUNG M, ENEMCHUKWU C and PREMINGER G (2018) ETHNIC BACKGROUND HAS MINIMAL IMPACT ON THE ETIOLOGY OF NEPHROLITHIASISJournal of Urology, VOL. 173, NO. 6, (2001-2004), Online publication date: 1-Jun-2005.PAK C, MOE O, SAKHAEE K, PETERSON R and POINDEXTER J (2018) PHYSICOCHEMICAL METABOLIC CHARACTERISTICS FOR CALCIUM OXALATE STONE FORMATION IN PATIENTS WITH GOUTY DIATHESISJournal of Urology, VOL. 173, NO. 5, (1606-1609), Online publication date: 1-May-2005.Shekarriz B and Stoller M (2018) Uric Acid Nephrolithiasis: Current Concepts and ControversiesJournal of Urology, VOL. 168, NO. 4 Part 1, (1307-1314), Online publication date: 1-Oct-2002. Volume 154Issue 5November 1995Page: 1665-1669 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Joseph Khatchadourian More articles by this author Glenn M. Preminger More articles by this author Peggy A. Whitson More articles by this author Beverley Adams-Huet More articles by this author Charles Y.C. Pak More articles by this author Expand All Advertisement PDF downloadLoading ...