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Mutagenicity of fume particles from metal arc welding on stainless steel in the Salmonella/microsome test

1978; Elsevier BV; Volume: 56; Issue: 3 Linguagem: Inglês

10.1016/0027-5107(78)90190-2

1873-135X

Jette Maxild, Margrethe Andersen, Pauli Kiel, Richard M. Stern,

Carcinogens and Genotoxicity Assessment

Mutagenic activity of fume particles produced by metal arc welding on stainless steel (ss) is demonstrated by using the Salmonella/microsome mutagenicity test described by Ames et al., with strain TA100 (base-pair substitution) and TA98 (frame-shift reversion). Results of a representative but limited selection of processes and materials show that mutagenic activity is a function of process and process parameters. Welding on stainless steel produces particles that are mutagenic, whereas welding on mild steel (ms) produces particles that are not. Manual metal arc (MMA) welding on stainless steel produces particles of higher mutagenic activity than does metal inert gas (MIG) welding, and fume particles produced by MIG welding under short-arc transfer conditions are more mutagenic than those produced by spray-arc transfer. Further studies of welding fumes (both particles and gases) must be performed to determine process parameters of significance for the mutagenic activity.