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GABA inhibits excitatory neurotransmission in rat pelvic ganglia

1985; Oxford University Press; Volume: 37; Issue: 5 Linguagem: Inglês

10.1111/j.2042-7158.1985.tb05081.x

2042-7158

Carlo Alberto Maggi, Paolo Santicioli, Alberto Meli,

Gastroesophageal reflux and treatments

Intravenous GABA inhibited, in a bicuculline-sensitive manner, contractions of the urinary bladder induced by preganglionic nerve stimulation in urethane anaesthetized rats, while it had no significant effect on contractions produced by postganglionic nerve stimulation. In addition, intravenous GABA strongly inhibited DMPP-induced bladder contractions; this effect was also prevented by bicuculline. These experiments suggest that GABA inhibits excitatory neurotransmission in rat pelvic ganglia through a mechanism involving, at least in part, the activation of postsynaptic GABA A receptors.