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Biocompatibility of various ferrite nanoparticles evaluated by in vitro cytotoxicity assays using HeLa cells

2009; Elsevier BV; Volume: 321; Issue: 10 Linguagem: Inglês

10.1016/j.jmmm.2009.02.058

1873-4766

Asahi Tomitaka, A. Hirukawa, Tsutomu Yamada, Shin MORISHITA, Yasushi Takemura,

Gold and Silver Nanoparticles Synthesis and Applications

Magnetic nanoparticles for thermotherapy must be biocompatible and possess high thermal efficiency as heating elements. The biocompatibility of Fe3O4 (20–30 nm), ZnFe2O4 (15–30 nm) and NiFe2O4 (20–30 nm) nanoparticles was studied using a cytotoxicity colony formation assay and a cell viability assay. The Fe3O4 sample was found to be biocompatible on HeLa cells. While ZnFe2O4 and NiFe2O4 were non-toxic at low concentrations, HeLa cells exhibited cytotoxic effects when exposed to concentrations of 100 μg/ml nanoparticles.