Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro
2009; Elsevier BV; Volume: 83; Issue: 2 Linguagem: Inglês
10.1016/j.antiviral.2009.05.002
ISSN1872-9096
AutoresGuifeng Wang, Liping Shi, Yudan Ren, Qun‐Fang Liu, Houfu Liu, Rujun Zhang, Zhuang Li, Fenghua Zhu, Pei‐Lan He, Wei Tang, Pei‐Zhen Tao, Chuan Li, Weimin Zhao, Jianping Zuo,
Tópico(s)Hepatitis C virus research
ResumoChlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
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