Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain
1992; Elsevier BV; Volume: 144; Issue: 1-2 Linguagem: Inglês
10.1016/0304-3940(92)90738-s
ISSN1872-7972
AutoresAtsumi Nitta, Yoshiko Furukawa, Kyozo Hayashi, Masayuki Hiramatsu, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima,
Tópico(s)Pain Mechanisms and Treatments
ResumoDenervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5–28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.
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