INDUCTION OF TOLERANCE TO SMALL BOWEL ALLOGRAFTS IN HIGH-RESPONDER RATS BY COMBINING ANTI-CD4 WITH CTLA4Ig1
1996; Wolters Kluwer; Volume: 62; Issue: 11 Linguagem: Inglês
10.1097/00007890-199612150-00001
ISSN1534-6080
AutoresDengping Yin, Howard Sankary, James S. Williams, Nancy Krieger, C. Garrison Fathman,
Tópico(s)Immune Cell Function and Interaction
ResumoThis study was designed to investigate the effectiveness of combined perioperative anti-CD4 and human (h)CTLA4Ig therapy in preventing allorejection of small bowel transplantation in high-responder Lewis rat recipients of ACI grafts. Anti-CD4 (5 mg/kg × 4 days) or hCTLA4Ig (0.5 mg/rat × 2 days) therapy alone delayed, but did not prevent, allograft rejection after small bowel transplantation of ACI into Lewis rats. All grafts were rejected in 18 and 10 days, respectively. However, a regimen of anti-CD4(5 mg/kg × 4 days) combined with hCTLA4Ig (0.5 mg/rat × 2 days) allowed indefinite survival of ACI small bowel allografts. Second donor-matched heart grafts were permanently accepted, whereas third-party(Sprague-Dawley) heart allografts were rejected by the tolerant recipients. These data suggest that these two reagents produced a synergistic effect in preventing allorejection of small bowel transplantation.
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