Chronic toxicity of Gynostemma pentaphyllum
2004; Elsevier BV; Volume: 75; Issue: 6 Linguagem: Inglês
10.1016/j.fitote.2004.04.010
ISSN1873-6971
AutoresAimmanas Attawish, Songphol Chivapat, Songphol Phadungpat, Jaree Bansiddhi, Yenchit Techadamrongsin, O. Mitrijit, Banchong Chaorai, Pranee Chavalittumrong,
Tópico(s)Phytochemistry and biological activity of medicinal plants
ResumoThe effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1). The extract was orally given to the five treatment groups at the doses of 6, 30, 150, 750 and 750 mg kg(-1) day(-1) for 24 weeks. The last group served as the recovery group. The results showed that the extract did not produce any significant dose-related changes. Therefore, it is concluded that the extract of G. pentaphyllum at the given doses did not produce any significant toxic effect in rats during 6-month period of the treatment.
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