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Presentation, diagnosis and management of limbal stem cell deficiency

2013; Medknow; Volume: 20; Issue: 1 Linguagem: Inglês

10.4103/0974-9233.106381

0975-1599

SophieX Deng, Kunjal Sejpal, Pejman Bakhtiari,

Corneal surgery and disorders

The human corneal surface epithelium is continuously repopulated by the limbal stem cells (LSCs). Limbal Stem Cell Deficiency (LSCD) can lead to corneal opacity and vascularization, with consequent visual impairment or blindness. Many acquired and congenital diseases can lead to LCSD by direct injury to the LSCs, destruction of LSC niche, or both. Based on the severity of the disease, LSCD can present with various symptoms and signs. Although LSCD can be detected clinically, laboratory tests are necessary to confirm the diagnosis and monitor the disease progression. This article concisely reviews the clinical presentation, techniques for diagnosis and management of LSCD.