Stelleralides A–C, Novel Potent Anti-HIV Daphnane-Type Diterpenoids from Stellera chamaejasm e L.
2011; American Chemical Society; Volume: 13; Issue: 11 Linguagem: Inglês
10.1021/ol200889s
ISSN1523-7060
AutoresYoshihisa Asada, Aya Sukemori, Takashi Watanabe, Kuber Jung Malla, Takafumi Yoshikawa, Wei Li, Kazuo Koike, Chin‐Ho Chen, Toshiyuki Akiyama, Keduo Qian, Kyoko Nakagawa‐Goto, Susan L. Morris‐Natschke, Kuo‐Hsiung Lee,
Tópico(s)Phytochemistry and Bioactive Compounds
ResumoThree novel 1-alkyldaphnane-type diterpenes, stelleralides A–C (4–6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4–6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC90 0.40 nM) with the lowest cytotoxicity (IC50 4.3 μM) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.
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