Molecular genetic alterations as potential prognostic indicators in colorectal carcinoma
1992; Wiley; Volume: 69; Issue: S6 Linguagem: Inglês
10.1002/1097-0142(19920315)69
ISSN1097-0142
Autores Tópico(s)Colorectal Cancer Treatments and Studies
ResumoThe molecular genetic alterations in colorectal carcinoma are among the best understood of any common human cancer.Identified abnormalities include both dominant-acting oncogenes (ras, myc, src) and suppressor genes which undergo inactivation or deletion (deleted in colorectal carcinoma gene [DCC], p53, adenomatous polyposis coli gene [APC], and probably loci on chromosomes 1p and 22ql.Accumulation of multiple abnormalities is evident in the adenoma-carcinoma sequence with a preferential order, and alteration of DNA methylation is an especially early event.Identification of molecular genetic markers useful for classification and staging of colorectal carcinoma is in its infancy.Deletion of the p53 gene on chromosome 17p, deletion of the DCC gene on 18q, and high fractional allelic loss (fraction of evaluable nonacrocentric autosomal arms with deletion) have been associated with distant metastases and with poorer prognosis in patients without initial evidence of disseminated disease.Additional studies are needed to determine the possible role of these alterations in clinical management.Cancer 1992; 69:1589-1591.The molecular genetic alterations in colorectal carcinoma are among the best understood of any common human cancer.'The nature of the disease itself has aided progress in this area.Neoplasms for study are readily available due to the high prevalence of this tumor in the US population: colorectal carcinoma is the
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