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BIBTEX RIS

Activity‐Dependent Neurotrophic Factor Peptide (ADNF9) Protects Neurons Against Oxidative Stress‐Induced Death

1999; Wiley; Volume: 73; Issue: 6 Linguagem: Inglês

10.1046/j.1471-4159.1999.0732341.x

ISSN

1471-4159

Autores

Gordon W. Glazner, André Boland, A Dresse, Douglas E. Brenneman, Illana Gozes, Mark P. Mattson,

Tópico(s)

Neuroscience and Neuropharmacology Research

Resumo

Abstract : Activity‐dependent neurotrophic factor (ADNF) and a 14‐amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β‐peptide, N ‐methyl‐ d ‐aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine‐amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO 4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.

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