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The Effect of Cycloserine on Pyridoxine‐Dependent Metabolism in Tuberculosis

1976; Wiley; Volume: 16; Issue: 8-9 Linguagem: Inglês

10.1002/j.1552-4604.1976.tb02419.x

1552-4604

Sreedhar Nair, William Maguire, Harry Baron, Richard Imbruce,

Tuberculosis Research and Epidemiology

The Journal of Clinical PharmacologyVolume 16, Issue 8-9 p. 439-443 The Effect of Cycloserine on Pyridoxine-Dependent Metabolism in Tuberculosis SREEDHAR NAIR M.D., SREEDHAR NAIR M.D. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this authorWILLIAM MAGUIRE Sc.B., WILLIAM MAGUIRE Sc.B. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this authorHARRY BARON Ph.D., HARRY BARON Ph.D. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this authorRICHARD IMBRUCE Ph.D., RICHARD IMBRUCE Ph.D. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this author SREEDHAR NAIR M.D., SREEDHAR NAIR M.D. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this authorWILLIAM MAGUIRE Sc.B., WILLIAM MAGUIRE Sc.B. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this authorHARRY BARON Ph.D., HARRY BARON Ph.D. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this authorRICHARD IMBRUCE Ph.D., RICHARD IMBRUCE Ph.D. Hinds Center for Respiratory Research, Norwalk Hospital, Norwalk, Connecticut, and Metropolitan Hospital Center, New York Medical College, New York, N.Y.Search for more papers by this author First published: August‐September 1976 https://doi.org/10.1002/j.1552-4604.1976.tb02419.xCitations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Epstein, I. G., Nair, K. G. S., and Boyd, L. J.: Cycloserine, a new antibiotic in the treatment of human pulmonary tuberculosis: a preliminary report. Antibiot. Med. 1: 80 (1955). 2 Epstein, I. G., Nair, K. G. S., and Boyd, L. J.: The treatment of human pulmonary tuberculosis with cycloserine: progress report. Dis. Chest 29(3): 241 (1956). 3 Epstein, I. G., Nair, K. G. S., Mulinos, M. G., Horiuchi, E., and Encarnacion, B.: Relation of plasma levels of cycloserine to oral dosage and clinical response in pulmonary tuberculosis. Fed. Proc. 19: 141 (1960). 4 Epstein, I. G., Nair, K. G. S., and Brown, L. J.: Cycloserine—Pyridoxine Combinations in the Control of Cycloserine Toxicity During Treatment of Chronic, Resistant Pulmonary Tuberculosis. Transactions of the 17th Veterans Administration-Armed Forces Conference on the Chemotherapy of Tuberculosis, Feb. 1958, p. 34. 5 Nair, K. G. S., Epstein, I. G., Mulinos, M. G., and Haber, A.: Reduction of Cycloserine Neurotoxicity by Pyridoxine. American Society of Pharmacologists and Experimental Therapists, Ann Arbor, Mich., Aug. 2528, 1958. 6 Epstein, I. G., Nair, K. G. S., Mulinos, M. G., and Haber, A.: Pyridoxine and Its Relation to Cycloserine Neurotoxicity. Antibiotics Annual 1958–59. New York, Medical Encyclopedia, 1959, p. 472. 7 White, A., Handler, P., and Smith, E. L.: Principles of Biochemistry. New York, McGraw Hill, 1973, p. 672. 8 Rose, D. P., and Toseland, P. A.: Urinary excretion of quinolinic acid and other tryptophan metabolites after deoxypyridoxine or oral contraceptive administration. Metabolism 22: 165 (1973). 9 Yess, N., Price, J. M., Brown, R. R., Swan, P. B., and Linkswiler, H.: Vitamin B6 depletion in man: urinary excretion of tryptophan metabolites. J. Nutr. 84: 229 (1964). 10 Harper, H. A.: Review of Physiological Chemistry. Los Altos, California, Lange Medical Publications, 1973, p. 101. 11 Jones, L. R.: Colorimetric determination of cycloserine, a new antibiotic. Anal. Chem. 28: 39 (1956). 12 Rosen, F., Lowy, R. S., and Sprince, H.: Rapid assay for xanthurenic acid in urine. Proc. Soc. Exper. Biol. Med. 77: 399 (1951). 13 Udenfriend, S., Weissbach, H., and Bodanski, D. F.: Biochemical findings relating to the action of serotonin. Ann. New York Acad. Sci. 66(3): 602 (1957). 14 Nair, S., and Baron, H.: Tryptophan metabolism in tuberculosis. Amer. Rev. Resp. Dis. 108: 977 (1973). Citing Literature Volume16, Issue8-9August‐September 1976Pages 439-443 ReferencesRelatedInformation