Hypophysectomy mitigates skeletal muscle fiber damage in hamster dystrophy
1985; Wiley; Volume: 17; Issue: 1 Linguagem: Inglês
10.1002/ana.410170114
ISSN1531-8249
AutoresGeorge Karpati, Peyton Jacob, Stirling Carpenter, S M Prescott,
Tópico(s)Exercise and Physiological Responses
ResumoAbstract Ablation of the pituitary gland by a rediofrequency lesion markedly retarded the musculoskeletal growth of young dystrophic hamsters. The prevalence of centronucleared muscle fibers, which is a reliable cumulative index of the microscopic patholgical expression of dystrophy, was drastically reduced in quadriceps muscles of 35‐ and 45‐day‐old hypophysectomized dystrophic hamsters, campared with sham‐operated controls. Mitigation of skeletal muscle fiber damage by musculoskeletal growth retardation may also occur in human dystrophy.
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