Antibodies to the Core Protein of Lymphadenopathy-Associated Virus (LAV) in Patients with AIDS
1984; American Association for the Advancement of Science; Volume: 225; Issue: 4659 Linguagem: Inglês
10.1126/science.6330889
ISSN1095-9203
AutoresV. S. Kalyanaraman, C D Cabradilla, Jane P. Getchell, R.B. Narayanan, E. H. Braff, Jean‐Claude Chermann, Françoise Barré‐Sinoussi, Luc Montagnier, Thomas J. Spira, Jonathan Kaplan, Daniel B. Fishbein, Harold W. Jaffe, J W Curran, D. P. Francis,
Tópico(s)Vector-Borne Animal Diseases
ResumoLymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the major core protein of LAV , p25 (molecular weight 25,000). Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors. Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25.
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