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Mild, Efficient Friedel−Crafts Acylations from Carboxylic Acids Using Cyanuric Chloride and AlCl 3

2008; American Chemical Society; Volume: 10; Issue: 13 Linguagem: Inglês

10.1021/ol800752v

1523-7060

Cyrous O. Kangani, Billy W. Day,

Synthesis of heterocyclic compounds

A mild method for Friedel−Crafts acylation with aromatic and aliphatic carboxylic acids using cyanuric chloride, pyridine, and AlCl3 was developed. Both inter- and intramolecular acylations were achieved at room temperature in high yield and in very short reaction times.