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The role of collagen in thrombosis and hemostasis

2004; Elsevier BV; Volume: 2; Issue: 4 Linguagem: Inglês

10.1111/j.1538-7836.2004.00665.x

1538-7933

Richard W. Farndale, J J Sixma, Michael J. Barnes, Philip G. de Groot,

Cell Adhesion Molecules Research

Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble scaffold which is essential for tissue integrity and which provides a surface for the attachment of other matrix constituents and for the adhesion of vascular cells. Thus collagens exercise important regulatory functions within the vasculature. At least 25 different types of collagen exist [1], a number of which, including major, widely distributed types I, III, IV, V and VI, occur in the vessel wall [2].