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Interspecies Conversion of Clostridium botulinum Type C to Clostridium novyi Type A by Bacteriophage

1974; American Association for the Advancement of Science; Volume: 186; Issue: 4162 Linguagem: Inglês

10.1126/science.186.4162.456

1095-9203

M. W. Eklund, F. T. Poysky, Jeffery Meyers, Gretchen A. Pelroy,

Clostridium difficile and Clostridium perfringens research

When Clostridium botulinum type C is cured of its prophage it simultaneously ceases to produce toxin. This nontoxigenic culture can then be converted to another toxigenic bacterial species, Clostridium novyi type A or to toxigenic Clostridium botulinum types C or D, by specific bacteriophages. The toxigenicity and type of toxin produced by these cultures depends upon the continued presence of these bacteriophages.