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Trimethylsilyl Trifluoromethanesulfonate- Accelerated Addition of Catalytically Generated Zinc Acetylides to Aldehydes

2009; American Chemical Society; Volume: 74; Issue: 7 Linguagem: Inglês

10.1021/jo900102w

1520-6904

C. Wade Downey, Brian D. Mahoney, Vincent R. Lipari,

Multicomponent Synthesis of Heterocycles

In the presence of TMSOTf, a wide variety of terminal acetylenes add rapidly and efficiently to aldehydes via a catalytically generated zinc acetylide. In the absence of TMSOTf, no reaction is observed under otherwise identical conditions.